item-0 at level 0: unspecified: group _root_
  item-1 at level 1: title: Proposal and Validation of a Cli ... ulation Diagnostic Criteria for Sepsis
  item-2 at level 1: paragraph: Kazuma Yamakawa; Department of E ... hi Tokushukai Hospital, Sapporo, Japan
  item-3 at level 1: text: Background Japanese Association  ... native criteria for sepsis management.
  item-4 at level 1: section_header: Introduction
    item-5 at level 2: text: Disseminated intravascular coagu ...  are widely used in clinical settings.
    item-6 at level 2: text: The JAAM DIC criteria have sever ... sis, this burden should be eliminated.
  item-7 at level 1: section_header: Study Population
    item-8 at level 2: text: This investigation was performed ... ., SOFA score of 2 or more points). 13
  item-9 at level 1: section_header: Data Collection and Definitions
    item-10 at level 2: text: A case report form was developed ... e was all-cause in-hospital mortality.
  item-11 at level 1: section_header: Newly Proposed Modified JAAM-2 DIC Criteria
    item-12 at level 2: text: We proposed novel DIC criteria n ... s set at 3 points or more ( Table 2 ).
  item-13 at level 1: section_header: Statistical Analysis
    item-14 at level 2: text: The overall effectiveness of ant ...  along with estimated survival curves.
  item-15 at level 1: section_header: Patient Characteristics
    item-16 at level 2: text: The patient flow diagram is show ... CU registry in the final study cohort.
    item-17 at level 2: text: Baseline characteristics of the  ...  the anticoagulant and control groups.
  item-18 at level 1: section_header: Prognostic Value of the Criteria
    item-19 at level 2: text: ROC curves for the original JAAM ... teria was considered to be equivalent.
  item-20 at level 1: section_header: Validity of the Criteria in Initiating Anticoagulation
    item-21 at level 2: text: Survival curves for the anticoag ... g DIC was considered to be equivalent.
  item-22 at level 1: section_header: Clinical Application of the Findings
    item-23 at level 2: text: Several different clinical pract ... tion and determining treatment timing.
    item-24 at level 2: text: Modification of the JAAM DIC cri ...  a totally clinical-friendly approach.
    item-25 at level 2: text: We intended to evaluate the seve ... 24 proposed by the ISTH in the future.
  item-26 at level 1: section_header: Strengths and Limitations
    item-27 at level 2: text: We acknowledge several limitatio ... tis should be conducted in the future.
  item-28 at level 1: section_header: Tables
  item-30 at level 1: table with [22x2]
    item-30 at level 2: caption: Table 1 Underlying diseases targeted by the JAAM-2 DIC criteria
  item-32 at level 1: table with [38x4]
    item-32 at level 2: caption: Table 3 Baseline characteristics of included sepsis patients in the three datasets
  item-33 at level 1: section_header: Figures
  item-35 at level 1: picture
    item-35 at level 2: caption: Fig. 1 Patient flow for the three datasets used in this study. DIC, disseminated intravascular coagulation; JAAM, Japanese Association for Acute Medicine; ROC, receiver operating characteristic.
  item-37 at level 1: picture
    item-37 at level 2: caption: Fig. 2 Receiver operating characteristic curves for original JAAM and modified JAAM-2 DIC criteria as predictors of in-hospital mortality. The solid line represents curves for JAAM-2, and the dotted line represents curves for original JAAM. (A) J-Septic DIC dataset, (B) FORECAST dataset, (C) SPICE dataset. DIC, disseminated intravascular coagulation; JAAM, Japanese Association for Acute Medicine.
  item-39 at level 1: picture
    item-39 at level 2: caption: Fig. 3 Adjusted estimated survival curves according to the original JAAM and modified JAAM-2 DIC status using the J-septic DIC dataset. (A) JAAM DIC score ≤ 3, (B) JAAM DIC score ≥ 4, (C) JAAM-2 DIC score ≤ 2, and (D) JAAM-2 DIC score ≥ 3. The solid line represents patients in the anticoagulant group, and the dotted line represents patients in the control group. DIC, disseminated intravascular coagulation; JAAM, Japanese Association for Acute Medicine.
  item-41 at level 1: picture
    item-41 at level 2: caption: Fig. 4 Adjusted estimated survival curves according to the original JAAM and modified JAAM-2 DIC status using the FORECAST dataset. (A) JAAM DIC score ≤ 3, (B) JAAM DIC score ≥ 4, (C) JAAM-2 DIC score ≤ 2, and (D) JAAM-2 DIC score ≥ 3. The solid line represents patients in the anticoagulant group, and the dotted line represents patients in the control group. DIC, disseminated intravascular coagulation; JAAM, Japanese Association for Acute Medicine.
  item-42 at level 1: section_header: References
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