docling/tests/data/groundtruth/docling_v2/pntd.0008301.nxml.itxt

item-0 at level 0: unspecified: group _root_
  item-1 at level 1: title: Risk factors associated with fai ... s: Results of a multi-country analysis
    item-2 at level 2: paragraph: Clara R. Burgert-Brucker; Global ... shington, DC, United States of America
    item-3 at level 2: section_header: Abstract
      item-4 at level 3: text: Achieving elimination of lymphat ... ine prevalence and/or lower elevation.
    item-5 at level 2: section_header: Introduction
      item-6 at level 3: text: Lymphatic filariasis (LF), a dis ... 8 countries remain endemic for LF [3].
      item-7 at level 3: text: The road to elimination as a pub ... t elimination be officially validated.
      item-8 at level 3: text: Pre-TAS include at least one sen ... me of day that blood can be taken [5].
    item-9 at level 2: section_header: Methods
      item-10 at level 3: text: Building on previous work, we de ... available global geospatial data sets.
    item-11 at level 2: section_header: Data sources
      item-12 at level 3: text: Information on baseline prevalen ...  publicly available sources (Table 1).
    item-13 at level 2: section_header: Outcome and covariate variables
      item-14 at level 3: text: The outcome of interest for this ... r than or equal to 1% Mf or 2% Ag [4].
      item-15 at level 3: text: Potential covariates were derive ... is and the final categorizations used.
    item-16 at level 2: section_header: Baseline prevalence
      item-17 at level 3: text: Baseline prevalence can be assum ... (2) using the cut-off of <10% or ≥10%.
    item-18 at level 2: section_header: Agent
      item-19 at level 3: text: In terms of differences in trans ... dazole (DEC-ALB)] from the MDA domain.
    item-20 at level 2: section_header: Environment
      item-21 at level 3: text: LF transmission intensity is inf ... dicates a higher level of “greenness.”
      item-22 at level 3: text: We included the socio-economic v ...  proxy for socio-economic status [33].
      item-23 at level 3: text: Finally, all or parts of distric ... s were co-endemic with onchocerciasis.
    item-24 at level 2: section_header: MDA
      item-25 at level 3: text: Treatment effectiveness depends  ... esent a threat to elimination [41,42].
    item-26 at level 2: section_header: Statistical analysis and modeling
      item-27 at level 3: text: Sensitivity analysis was perform ... ot have been truly LF-endemic [43,44].
    item-28 at level 2: section_header: Results
      item-29 at level 3: text: The overall pre-TAS pass rate fo ... ts had baseline prevalences below 20%.
      item-30 at level 3: text: Fig 3 shows the unadjusted analy ... overage, and sufficient rounds of MDA.
      item-31 at level 3: text: Fig 4 shows the risk ratio resul ... of failing pre-TAS (95% CI 1.95–4.83).
      item-32 at level 3: text: Sensitivity analyses were conduc ... gnified by large confidence intervals.
      item-33 at level 3: text: Overall 74 districts in the data ... or 51% of all the failures (38 of 74).
    item-34 at level 2: section_header: Discussion
      item-35 at level 3: text: This paper reports for the first ... ctors associated with TAS failure [7].
      item-36 at level 3: text: Though diagnostic test used was  ...  FTS was more sensitive than ICT [45].
      item-37 at level 3: text: Elevation was the only environme ... ich impact vector chances of survival.
      item-38 at level 3: text: The small number of failures ove ... search has shown the opposite [15,16].
      item-39 at level 3: text: All other variables included in  ... are not necessary to lower prevalence.
      item-40 at level 3: text: Limitations to this study includ ...  reducing LF prevalence [41,48,51–53].
    item-41 at level 2: section_header: Tables
      item-42 at level 3: table with [18x8]
        item-42 at level 4: caption: Table 1 Categorization of potential factors influencing pre-TAS results.
      item-43 at level 3: table with [11x6]
        item-43 at level 4: caption: Table 2 Adjusted risk ratios for pre-TAS failure from log-binomial model sensitivity analysis.
    item-44 at level 2: section_header: Figures
    item-45 at level 2: picture
      item-45 at level 3: caption: Fig 1 Number of pre-TAS by country.
    item-46 at level 2: picture
      item-46 at level 3: caption: Fig 2 District-level baseline prevalence by country.
    item-47 at level 2: picture
      item-47 at level 3: caption: Fig 3 Percent pre-TAS failure by each characteristic (unadjusted).
    item-48 at level 2: picture
      item-48 at level 3: caption: Fig 4 Adjusted risk ratios for pre-TAS failure with 95% Confidence Interval from log-binomial model.
    item-49 at level 2: picture
      item-49 at level 3: caption: Fig 5 Analysis of failures by model combinations.
    item-50 at level 2: section_header: References
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